Est. 2012 · 10,000+ Patients · All 50 States
Weight loss, prescribed by a real clinic.
GLP-1 treatment from $96.05/month — everything included, no membership fee, full refund if the provider declines.
~5 minutes · Private · Full refund if not approved
No membership fee · A licensed provider decides — declined = full refund · Injection supplies & cold shipping included
What the trials showed
15–21%
average body-weight loss in the landmark trials of the branded medications (STEP 1 · SURMOUNT-1), taken at full doses alongside diet and exercise. Slide to see what that range averaged at your weight.
15–21% of 230 lbs, per the landmark trials of the branded medications (STEP 1 · SURMOUNT-1), taken alongside diet and exercise — an average from the trials, not a promise. Compounded medications are separate, non-FDA-approved preparations. Individual results vary; no outcome is guaranteed.
Find my plan →~60 seconds · Private · Full refund if not approved
New or not sure where to start?
Find my plan
Six quick questions — we'll suggest a starting plan with the price up front. A licensed provider makes the final call on everything.
Start — about 60 secondsPrivate · Free · Full refund if not approved
Already on a GLP-1?
I know my dose
Keep your dose — pick your medication and strength and see your exact price up front. No quiz, no membership, no games.
Keep your dose. No competitor offers this.
Compounded Semaglutide
Lowest costGLP-1 · the lowest-cost start
3-month starter (0.25 → 0.5 → 1 mg weekly) with auto-refill · billed $288.15 per shipment
Compounded Tirzepatide
Strongest trialsDual GIP + GLP-1 · the strongest published trial results
3-month plan with auto-refill · billed $360.40 per shipment
Starter · Months 1–3
2.5 → 5 → 7.5 mg weekly
Your price at every dose — shown up front
Tirzepatide, per month on the 3-month plan with auto-refill (15% off, cancel anytime) · the smaller figure is the 1-month one-time supply · every price includes the medication, provider review, injection supplies, and cold shipping. When your provider steps your dose up, this is the whole price change — no membership fee, no surprise tiers.
Semaglutide runs $96.05–$127.22/mo on the same basis — every dose is priced on the semaglutide page.
All-in — medication, provider review, supplies, cold shipping
Tap any program to see its full fee structure. Competitor pricing checked 2026-08-16 from public pages and published sources; structures change — see each brand’s site for current terms.
As seen & heard on
From Intake To Ongoing Care
The same medical process as an in-person weight-management visit — without the appointment. A licensed provider makes every prescribing decision, start to finish.
[01]
5-minute intake
Check eligibility, pick a plan, and complete a structured health questionnaire online. No appointment, no video call, no waiting room.
[02]
Provider review
A licensed provider reviews your intake, typically within 24–48 hours, and decides whether treatment is appropriate. If it isn't, you get a full refund.
[03]
Cold-shipped to your door
Medication ships from a licensed U.S. pharmacy in cold-chain packaging, injection supplies included, tracking on every box. One-time by default — auto-refill is optional.
[04]
Titration support
Doses start low and step up gradually as tolerated. Your provider sets every adjustment on the standard titration schedule — never on autopilot.
[05]
Ongoing care
Message your care team any time. Side-effect questions, dose concerns, plan changes — a real clinic stays on the other end.
A Licensed Provider Decides —
Not An Algorithm
Affinity Direct is the online branch of our clinic network, treating patients in person since 2012. Your intake is reviewed by a licensed clinician, just like in our exam rooms, who can approve, request more info, or decline.
Licensed In Your State
The provider who reviews your intake holds an active license in the state where you live — that's what makes the prescription legitimate.
A Real Medical Decision
Your full intake — history, medications, contraindications — is reviewed by a clinician. Approval is never automatic, and "no" is a real answer.
Typically 24–48 Hours
Most reviews complete within two days. If the provider needs more detail, they may request a quick video visit at no extra cost.
Declined = Full Refund
If treatment isn't appropriate for you, the provider declines it and we refund the entire amount. You never pay for medication you can't receive.
Compare The Two Medications
Both reduce appetite with a once-weekly injection. The honest differences, so you and your provider can pick the right starting point.
GLP-1
Semaglutide
How it works
GLP-1 receptor agonist — reduces appetite and slows stomach emptying
Results in clinical trials of the branded versions
Average weight loss of about 15% of body weight over 68 weeks (STEP 1 trial)
Injection schedule
Once weekly
Starting price at Affinity
From $96.05/mo effective with auto-refill · $159 one-time (1-month supply)
Included in the compound
Semaglutide
Dual GIP + GLP-1
Tirzepatide
How it works
Dual GIP + GLP-1 receptor agonist — acts on two hunger-regulating pathways
Results in clinical trials of the branded versions
Average weight loss of up to about 21% of body weight over 72 weeks (SURMOUNT-1 trial, highest dose)
Injection schedule
Once weekly
Starting price at Affinity
From $120.14/mo effective with auto-refill · $174 one-time (1-month supply)
Included in the compound
Tirzepatide + B12, Glycine, B6, L-Carnitine
Swipe to compare
Trial figures describe the FDA-approved branded medications studied at their full maintenance doses alongside diet and exercise. Individual results vary and no outcome is guaranteed. Compounded medications are not FDA-approved. A licensed provider decides which medication and dose, if any, is appropriate for you.
What The Trials Actually Showed
These figures come from the landmark trials of the FDA-approved branded versions, taken at full doses alongside diet and exercise. We cite them because they are the best available evidence — not as a promise about your result.
~15% average Body-Weight Loss
In the STEP 1 trial of the FDA-approved branded version (2.4 mg weekly alongside diet and exercise), adults lost an average of about 15% of body weight over 68 weeks. Individual results vary and no outcome is guaranteed; compounded semaglutide is a separate, non-FDA-approved preparation.
Wilding et al., NEJM (2021) — STEP 1
Up to ~21% average Body-Weight Loss
In the SURMOUNT-1 trial of the FDA-approved branded version (highest dose alongside diet and exercise), adults lost an average of up to about 21% of body weight over 72 weeks. Individual results vary and no outcome is guaranteed; compounded tirzepatide is a separate, non-FDA-approved preparation.
Jastreboff et al., NEJM (2022) — SURMOUNT-1
Who Qualifies — Honestly
GLP-1 therapy isn't for everyone, and we won't pretend it is. Providers generally consider treatment for adults who meet the standard medical criteria below. Our eligibility check screens you before you pay — and a licensed provider always makes the final decision after reviewing your full health intake.
BMI 25 Or Higher — Standard Dosing
The full dosing range is typically appropriate, including the higher weekly doses as you titrate up. Your provider confirms the right dose.
BMI 23–24.9 — Maintenance / Starting Dose
Providers typically use the lower end of the weekly dose range — a maintenance or starting dose protocol.
BMI 21–22.9 — Microdose Protocol
Providers typically start with a microdose protocol at the lowest weekly dose. Below a BMI of 21, GLP-1 therapy isn’t appropriate — our eligibility check tells you before you pay, not after.
Read This Before You Start
The three things patients ask about most in the first week — the injection itself, how the medication actually works, and why the compounded version costs a fraction of the brand.
Medical weight loss is available in all 50 states. See where we treat →
Weight Loss — Common Questions
Everything you need to know before getting started
No. We offer compounded semaglutide and compounded tirzepatide prepared by licensed U.S. compounding pharmacies. They contain the same active ingredient classes as the branded medications but are separate products, and compounded medications are not FDA-approved. A licensed provider reviews your health intake and decides whether treatment is appropriate for you.
Yes — and we handle that step. After checkout you complete a health intake, and a licensed provider reviews it, typically within 24–48 hours. If the provider determines treatment is appropriate, they issue the prescription and your medication ships from the pharmacy. If not, you receive a full refund.
Our providers consider GLP-1-class therapy for adults with a BMI of 21 or higher. Dosing follows your BMI: 21–22.9 typically starts on a microdose protocol at the lowest weekly dose, 23–24.9 on a maintenance/starting dose, and 25+ uses standard dosing including the higher weekly doses. The final decision — including your dose — is always made by the licensed provider who reviews your intake.
Compounded semaglutide runs from $96.05/mo and compounded tirzepatide from $120.14/mo effective on a 3-month plan with the optional Subscribe & Save auto-refill (15% off, cancel anytime — never required); 1-month one-time supplies start at $159 and $174. Every dose has its own published price, and every price includes the medication, injection supplies, cold shipping, the medical review, and provider follow-up. No membership fees.
No. Every Affinity Direct weight-loss order is a one-time purchase by default — checkout never enrolls you in recurring billing, and a one-time order simply ends after delivery with no renewal and no future charges. Auto-refill (Subscribe & Save, 15% off) is a separate option you must actively select at checkout; if you choose it, you can pause or cancel it anytime from your patient portal with no fees and no commitment.
Your dose selection is a request, not a prescription. Choose the dose your current plan calls for — or a starter protocol if you are new — and the licensed provider who reviews your intake confirms or adjusts it. New patients typically start at the lowest dose and titrate up gradually as tolerated.
You receive a full refund. You are charged at checkout, and if the reviewing provider determines treatment is not appropriate for you, we refund the entire amount.
Your medication ships from a licensed U.S. pharmacy in cold-chain packaging with discreet labeling, and injection supplies are included. 3-month supplies arrive as one shipment. Tracking is provided for every shipment.
The most common side effects of GLP-1-class medications are nausea, constipation, diarrhea, and reduced appetite, especially during the first weeks of a dose increase. Your provider starts at a low dose and increases gradually to reduce these effects, and you can message your care team at any time.
Affinity Direct is the online division of Affinity Whole Health — a real Midwest clinic network established in 2012 with 4 locations and more than 10,000 patients treated. We are HIPAA compliant, and licensed providers review every order.
See If You Qualify.
The eligibility check takes about two minutes and is free. You only pay if you qualify and choose a plan — and only keep paying if a provider approves treatment.
Medical Disclosure
Important safety information: Compounded semaglutide and compounded tirzepatide are prepared by licensed U.S. compounding pharmacies and are not FDA-approved. The FDA does not review compounded medications for safety, effectiveness, or quality before they are dispensed. Prescription weight-loss medication is only available if a licensed provider determines it is appropriate for you after reviewing your health intake — your dose selection is a request, and the provider sets the actual dose. Individual results vary and no amount of weight loss is guaranteed. GLP-1-class medications should be used alongside a reduced-calorie diet and increased physical activity.