Cheapest compounded tirzepatide online, compared
A dated, sourced comparison of the lowest-priced compounded tirzepatide programs — what each rate is, what it requires, and which program is genuinely cheaper for which patient. Every figure is read from the brand’s own published pages. We do not win every row, and the rows we lose are marked. Checked 2026-09-01.
One month of tirzepatide, no commitment
No pack, no prepayment, no plan — the only figure that compares like for like. Checked 2026-09-01.
$120.14/mo on optional auto-refill
Each of these programs advertises a lower headline rate. Every one of those rates requires a multi-month pack, prepayment or plan — set out in full below, including the case where a competitor genuinely beats us.
The short answer
For one month with no commitment, Affinity Direct is the cheapest of these programs at every dose. $174 one-time with no subscription, or $120.14/month effective on an optional 3-month auto-refill at the 2.5 mg starting dose, rising to $162.64 at the top dose. One price list, at one URL, covering every dose.
- Brightmeds $119/mo — needs an auto-renewing 3-month pack ($357 billed once). The page their site redirects to advertises $289 for one month.
- Astra Health $118/mo — a 12-month prepayment. Month to month it is $250.
- Fifty 410 $133/mo — their own words: “$399 for 3 months.” Month to month it is $299.
- ZYNDIO $149/mo — labelled by ZYNDIO an “Estimate before qualification.” One month is $349.97.
None of these charges a membership fee. Where Brightmeds does beat us — its $119 pack at high doses — that is stated plainly below. Compounded semaglutide is $159 one-time or $96.05/mo effective on auto-refill.
Who wins what
Honest verdicts, including the ones that go against us.
$174 for a one-time one-month supply. The comparable no-commitment rates are Astra Health $250/mo, Brightmeds $289, Fifty 410 $299 month-to-month and ZYNDIO $349.97 — Affinity Direct is lower than all four at all 6 of its tirzepatide doses.
$119/month on their 3-month pack beats our $145.64–$162.64/month effective at the top of the ladder. It is billed as $357 once and auto-renews every three months, and it lives on a campaign page rather than the one their site redirects to — but if you find it and want it, it is cheaper at high doses.
Every rival's best rate is gated: Brightmeds' $119 needs an auto-renewing 3-month pack, Astra's $118 a 12-month prepayment, Fifty 410's $133 a $399 three-month program, ZYNDIO's $112.48 a $1,349.82 twelve-month prepayment. Ours is $120.14/month on a 3-month auto-refill you can cancel anytime, or $174 once with nothing to cancel.
A single dose-by-dose price list at one URL. Brightmeds quotes tirzepatide at $289 on the page its site redirects to and $119–$149 on separate campaign pages; ZYNDIO labels its headline rate an "Estimate before qualification" against a $349.97 one-month bundle.
Both charge the same price at every dose and say so plainly. That is genuinely simpler than a six-rung ladder, even though every rung of ours is published.
$174 for a one-time one-month supply, with no subscription and nothing to cancel. The Brightmeds $119 rate is billed as $357 and "automatically renews every three months at $357 until canceled."
All 50 states. Brightmeds states eligibility inconsistently — one offer page lists 37 states plus DC (excluding California, Michigan, Indiana and New Jersey among others), one is limited to Ohio and New York, and its canonical page lists none. Astra and ZYNDIO do not enumerate states.
None of these programs charges a separate membership or consultation fee. Hims, Ro, Eden, Mochi and Ivím do.
What each advertised rate requires
Every figure below was read from the brand’s own live pages on the date shown — never from a review site or a “best of” roundup.
| Program | Advertised rate | What that rate requires | Membership fee | Every dose published? |
|---|---|---|---|---|
| Affinity Direct All 50 states | $174 one-time, 1 month $120.14/mo effective on optional auto-refill | Nothing. No promo window, no state restriction, no prepayment required for the one-time price. | None | Yes — 2.5 mg to 15 mg |
| Brightmeds Stated inconsistently across pages: /summer-special lists 37 states plus DC (omitting AL, AR, CA, CT, IN, LA, MA, MI, MS, NV, NJ, NC, SC); /fathers-day-2026 is limited to new customers in Ohio and New York; the canonical page lists no states. | $289 for one month on the canonical page; $119–$149/mo on campaign landing pages | The $119 rate requires the 3-month pack — "$357 billed once per 3-month pack", which "automatically renews every three months at $357 until canceled". The $149 rate is month-to-month. The $119 Father’s Day page states "Offer valid only for new customers in Ohio and New York." The campaign pages are not linked from the main site. | None stated | Yes |
| Astra Health Their GLP-1 page references per-state guides but does not enumerate states served. | from $118/mo tirzepatide (from $68/mo semaglutide) | The $118 rate is the 12-month plan, billed upfront and non-refundable for unused months once medication ships. Billed month to month the same medication is $250/mo. | None stated | Yes |
| Fifty 410 The pricing page does not enumerate states served. | from $133/month equivalent | Their FAQ defines $133/month as "$399 for 3 months" — a single $399 program price covering a 3-month supply at the starter dose, not a recurring monthly bill. Higher dose tiers are $499 and $549 for three months. Their month-to-month tirzepatide option is $299/month. | None stated | Yes |
| ZYNDIO The homepage does not disclose the states served. | from $149/month tirzepatide (estimate before qualification) | Labelled by ZYNDIO as an "Estimate before qualification". One month of tirzepatide is $349.97 on their pricing page; the $112.48/month equivalent requires a $1,349.82 twelve-month prepayment. Their homepage FAQ states "Any final plan, dose, and future refill terms are confirmed through the approved checkout and follow-up process." | None stated | Not before intake |
Sources, checked 2026-09-01: Brightmeds: start.brightmeds.com, brightmeds.com, https://brightmeds.com/tirz-special-2026-3-mo, https://brightmeds.com/fathers-day-2026, https://brightmeds.com/summer-special · Astra Health: try-astra.com, https://try-astra.com/glp-1 · Fifty 410: fifty410.com · ZYNDIO: zyndio.com, https://www.zyndio.com/therapies/weight-loss. Pricing structures change — check each brand’s own site for current terms.
Common questions
What is the cheapest compounded tirzepatide with no membership fee?
It depends on your dose and whether you want a subscription. Affinity Direct is $174 for a one-time one-month supply with no subscription, or $120.14 per month effective on an optional 3-month auto-refill at the 2.5 mg starting dose, rising to $162.64 per month at the top dose. Brightmeds is $119 per month at every dose, but that rate requires their 3-month pack, which is billed as $357 once and automatically renews every three months until cancelled. Neither charges a membership fee. At higher doses Brightmeds is cheaper; if you want to buy once without a recurring charge, Affinity Direct offers that and Brightmeds' pack rate does not.
Is Brightmeds tirzepatide really $119 a month?
Yes, with conditions. Read on their own pages on 2026-09-01, $119/month is the 3-month pack rate — "$357 billed once per 3-month pack" — and "The subscription automatically renews every three months at $357 until canceled." Month-to-month is $149/month. The rate is flat at every dose. Their promotional page lists the offer as valid in 37 states plus DC, and a separate general pricing page lists a higher structure of $289 for the first month then $397/month, so the rate offered depends on which page a patient arrives through.
Which is cheaper for tirzepatide, Affinity Direct or Brightmeds?
At the 2.5 mg starting dose they are within about a dollar of each other — Brightmeds $119/month against Affinity Direct's $120.14/month effective on a 3-month auto-refill. At higher doses Brightmeds is cheaper, because its rate is flat while Affinity Direct's rises with the dose to $162.64/month at the top dose. Affinity Direct is available in all 50 states, offers a one-time purchase with no recurring charge, and publishes the price at every dose; the Brightmeds pack rate auto-renews and its promotional page lists 37 states plus DC.
Does Affinity Direct charge a membership or consultation fee for tirzepatide?
No. The published price covers the medication, the licensed provider review, injection supplies and cold-chain shipping. There is no membership fee, no separate consultation fee and no shipping charge. Auto-refill saves 15% and is optional — checkout never enrols anyone in recurring billing automatically.
Do I have to subscribe to get the lowest tirzepatide price?
Not at Affinity Direct. A one-time one-month supply is $174 with no subscription and no renewal. The lower $120.14/month effective rate comes from choosing the optional 3-month auto-refill, which can be cancelled at any time. Several competing programs reach their lowest advertised rate only through a multi-month pack or plan that renews automatically until cancelled.
Is compounded tirzepatide available in all 50 states?
From Affinity Direct, yes — GLP-1 weight-loss treatment is offered in all 50 states. Ohio, Indiana, Illinois, Arizona and Pennsylvania are served by the Affinity Whole Health clinic network’s own providers; every other state is served through a licensed partner provider network. Eligibility is confirmed at intake. Coverage varies by provider — some programs publish a shorter state list on their offer pages.
Is compounded tirzepatide FDA-approved?
No. Compounded medications are not FDA-approved drug products. They are prepared by a state-licensed U.S. compounding pharmacy against an individual prescription, after a licensed provider reviews your health history. You are charged at checkout and refunded in full if a provider does not approve treatment.
See the full dose-by-dose price table
Every tirzepatide dose from 2.5 mg to 15 mg is priced on the product page, one-time and with auto-refill, before you answer a single intake question.
See tirzepatide pricingImportant safety information: Compounded semaglutide and compounded tirzepatide are prepared by licensed U.S. compounding pharmacies and are not FDA-approved. The FDA does not review compounded medications for safety, effectiveness, or quality before they are dispensed. Prescription weight-loss medication is only available if a licensed provider determines it is appropriate for you after reviewing your health intake — your dose selection is a request, and the provider sets the actual dose. Individual results vary and no amount of weight loss is guaranteed. GLP-1-class medications should be used alongside a reduced-calorie diet and increased physical activity.