Tesamorelin — Full-Length GHRH Analog

Tesamorelin is a synthetic analog of growth-hormone-releasing hormone (GHRH), the hormone the hypothalamus uses to signal the pituitary gland. It contains all 44 amino acids of natural GHRH, with a small chemical group added at one end so enzymes break it down more slowly. Like the body's own GHRH, it prompts the pituitary to release its own growth hormone.

No. Compounded tesamorelin — what Affinity Direct sells — is not an FDA-approved drug product (a brand-name tesamorelin is, for one specific use). Yours is prepared by a state-licensed U.S. compounding pharmacy for your individual prescription, and only after a licensed provider reviews your health history and decides it is appropriate for you. The FDA does not review compounded medications for safety, effectiveness or quality.

Tesamorelin (3 mg/mL) is sold as a 1-month plan (2 × 5 mL, $299 one-time or $254.15 with auto-refill) or a 2-month plan (3 × 5 mL, $449 one-time or $381.65 with auto-refill). That is what ships and what you pay — your provider sets your dose when they write the prescription, so how long a plan lasts depends on the dose they prescribe. Auto-refill is optional, takes 15% off either plan and cancels anytime; free syringes, alcohol prep pads and cold-chain shipping are included on both.

Both are GHRH analogs that act on the same pituitary receptor. Sermorelin is the first 29 amino acids of natural GHRH; tesamorelin is the full 44-amino-acid sequence with a stabilizing group added, so it lasts longer in the body. They have not been compared head to head in people, and whether either is appropriate for you is your provider's decision.

We don't promise specific results or a timeline. Compounded tesamorelin is not FDA-approved, the human trials that exist studied the brand-name product for one specific use, and how people respond varies. Your licensed provider talks through realistic expectations for your health history and sets your dose and schedule when they write your prescription.

The most commonly reported reactions are redness, itching or swelling at the injection site, joint or muscle pain, pain in the arms or legs, swelling in the hands or feet, and numbness or tingling. Tesamorelin can raise blood sugar, so tell your provider if you have diabetes or prediabetes. As with any injectable, an allergic reaction is possible. Message your care team if anything doesn't feel right.

Tesamorelin is not used during pregnancy, by anyone with active cancer, or after pituitary surgery, a pituitary tumor or radiation to the head. It is also not used by anyone allergic to any component of the formulation. Your provider reviews your full health history — including blood sugar and any cancer history — during intake and won't prescribe it if it isn't appropriate for you.

No — there's no need to come into a clinic. It is given at home with a small, short needle into fatty tissue, and every order ships with sterile syringes and alcohol prep pads, along with step-by-step guidance. Your care team is a message away if you want a walkthrough.