MOTS-C Mitochondrial-Derived Peptide

MOTS-C is a 16-amino-acid peptide encoded inside mitochondrial DNA — the small genome inside the cell's energy-producing mitochondria — rather than in the cell's nucleus. The body makes its own MOTS-C; compounded MOTS-C is a synthetic copy of that sequence.

Research describes MOTS-C activating AMPK, the enzyme cells use to sense low fuel, and published human studies have measured the body's own circulating MOTS-C, which rises with exercise. Studies of MOTS-C given as a medication are nearly all in animals and cells, so its effects in people are not established.

No. Compounded MOTS-C is not an FDA-approved drug product. In October 2026 HHS announced an interim policy under which FDA does not intend to take enforcement action against pharmacies compounding single-ingredient BPC-157, TB-500 or MOTS-C under specific conditions — that is not FDA approval. Yours is compounded by a state-licensed U.S. pharmacy for your individual prescription, and only after a licensed provider reviews your health history and decides it is appropriate for you.

MOTS-C (2 mg/mL) is sold as a 1-month plan (5 mL, $219 one-time or $186.15 with auto-refill) or a 2-month plan (2 × 5 mL, $349 one-time or $296.65 with auto-refill) — the 2-month plan saves $89 vs. two 1-month orders. That is what ships and what you pay — your provider sets your dose when they write the prescription, so how long a plan lasts depends on the dose they prescribe. Auto-refill is optional, takes 15% off either plan and cancels anytime; free syringes, alcohol prep pads and cold-chain shipping are included on both.

We don't promise specific results or a timeline. Compounded MOTS-C is not FDA-approved, most published research on it is in animals and cells, and how people respond varies. Your licensed provider talks through realistic expectations for your health history and sets your dose and schedule when they write your prescription.

Human data on MOTS-C given as a medication is limited, so its side-effect profile in people is not well characterized. Reported reactions are usually mild — redness or itching at the injection site, headache, tiredness or nausea. Because it is studied for how cells use glucose, tell your provider if you take medication for diabetes. As with any injectable, an allergic reaction is possible.

MOTS-C is not used during pregnancy or breastfeeding, or by anyone allergic to any component of the formulation. Your provider also reviews conditions such as diabetes, kidney disease and any cancer history before deciding, and won't prescribe it if it isn't appropriate for you.

No — there's no need to come into a clinic. It is given at home with a small, short needle into fatty tissue, and every order ships with sterile syringes and alcohol prep pads, along with step-by-step guidance. Your care team is a message away if you want a walkthrough.